Effect of Hepatic Dysfunction on Oral Cyclosporine Pharmacokinetics in Marrow Transplant Patients
نویسندگان
چکیده
The effect of hepatic dysfunction. defined as abnormal serum bilirubin level. on oral cyclosporine (CSP) pharmacokinetics was examined in 28 marrow transplant patients who received CSP for prophylaxis of graft-v-host disease. Serum CSP concentrations were measured by radioimmunoassay. Forty-one concentration-time courses were studied. divided among patients with no (< 1 .2 mg/dL). mild (1.2 to 2.0 mgldL). and moderate (2.0 to 5.0 mg/dL) hepatic dysfunction. CSP elimination. as determined by
منابع مشابه
Effect of hepatic dysfunction on oral cyclosporin pharmacokinetics in marrow transplant patients.
The effect of hepatic dysfunction, defined as abnormal serum bilirubin level, on oral cyclosporin (CSP) pharmacokinetics was examined in 28 marrow transplant patients who received CSP for prophylaxis of graft-v-host disease. Serum CSP concentrations were measured by radioimmunoassay. Forty-one concentration-time courses were studied, divided among patients with no (less than 1.2 mg/dL), mild (1...
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